Child welfare clinics established in a rural Jamaican community for research purposes are described. These special clinics were able to devote more resources to the care of their children than is usual, yet the growth and health of these children were very similar to those in another group to whom this service was not available and who attended routine government welfare clinics only infrequently.

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

Sensory processing dysfunction is characterized by a behaviorally observed difference in the response to sensory information from the environment. While the cerebellum is involved in normal sensory processing, it has not yet been examined in SPD. Diffusion tensor imaging scans of children with SPD and typically developing controls were compared for fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity across the following cerebellar tracts: the middle cerebellar peduncles, superior cerebellar peduncles, and cerebral peduncles. Compared to TDC, children with SPD (...) show reduced microstructural integrity of the SCP and MCP, characterized by reduced FA and increased MD and RD, which correlates with abnormal auditory behavior, multisensory integration, and attention, but not tactile behavior or direct measures of auditory discrimination. In contradistinction, decreased CP microstructural integrity in SPD correlates with abnormal tactile and auditory behavior and direct measures of auditory discrimination, but not multisensory integration or attention. Hence, altered cerebellar white matter organization is associated with complex sensory behavior and attention in SPD, which prompts further consideration of diagnostic measures and treatments to better serve affected individuals. (shrink)

Over the past decade, Convergence Research has increasingly gained prominence as a research, development, and innovation (RDI) strategy to address grand societal challenges. However, a dearth of research-based evidence is available to aid researchers, research teams, and institutions with navigating the complexities attendant to the specifics of Convergence Research. This paper presents a multilevel research agenda that accounts for an integral understanding of Convergence Research as a complex adaptive system. Furthermore, by developing a framework that accounts for ancillary, yet essential, (...) systems associated with Convergence Research, we enrich the agenda with a literature-steeped discussion that considers how systems-based practices of collaboration, inquiry, and context interact with the processes and products of Convergence Research. Finally, we synthesize and apply insights from the reviewed literature by providing paths for empirical exploration emphasizing systems-based practices. In so doing, we delineate an extended boundary for a research stream that both clarifies and enlarges our understanding of Convergence Research as a ‘system-of-systems’. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Modern Indian nationalist thought has dealt with political ideas such as freedom, equality, liberty, democracy, so on and so forth. The idea of freedom received enough attention on the part of most of the modern Indian political thinkers. However, the idea of freedom as envisaged by the nationalist thinkers did not receive positive response from the other stream of modern Indian thought. Dalit-Bahujan political thinkers questioned the narration of freedom as propagated by the nationalist thinkers. Nationalist thinkers aspired for universal (...) values and at the same time reaffirmed ancient religious principles. Such effort was questioned and doubted by the other thinkers of modern India. Thus, one can find different narrations of freedom, such as social, economic and political. The social categories such as caste, class and gender became bases for their narration on the idea of freedom. The ideas and arguments of B. G. Tilak, M. K. Gandhi, Pandita Ramabai, Jyotiba Phule, B. R. Ambedkar E. M. S. Namboodripad and others would help in larger understanding of the idea of freedom. (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

Hastings Center Report, Volume 51, Issue 5, Page 53-55, September‐October 2021.

Two algebraic structures, the contrapositionally complemented Heyting algebra (ccHa) and the contrapositionally |$\vee $| complemented Heyting algebra (c|$\vee $|cHa), are studied. The salient feature of these algebras is that there are two negations, one intuitionistic and another minimal in nature, along with a condition connecting the two operators. Properties of these algebras are discussed, examples are given and comparisons are made with relevant algebras. Intuitionistic Logic with Minimal Negation (ILM) corresponding to ccHas and its extension |${\textrm {ILM}}$|-|${\vee }$| for c|$\vee (...) $|cHas are then investigated. Besides its relations with intuitionistic and minimal logics, ILM is observed to be related to Peirce’s logic and Vakarelov’s logic MIN. With a focus on properties of the two negations, relational semantics for ILM and |${\textrm {ILM}}$|-|${\vee }$| are obtained with respect to four classes of frames, and inter-translations between the classes preserving truth and validity are provided. ILM and |${\textrm {ILM}}$|-|${\vee }$| are shown to have the finite model property with respect to these classes of frames and proved to be decidable. Extracting features of the two negations in the algebras, a further investigation is made, following logical studies of negations that define the operators independently of the binary operator of implication. Using Dunn’s logical framework for the purpose, two logics |$K_{im}$| and |$K_{im-{\vee }}$| are discussed, where the language does not include implication. The |$K_{im}$|-algebras are reducts of ccHas and are different from relevant algebraic structures having two negations. The negations in the |$K_{im}$|-algebras and |$K_{im-{\vee }}$|-algebras are shown to occupy distinct positions in an enhanced form of Dunn’s kite of negations. Relational semantics for |$K_{im}$| and |$K_{im-{\vee }}$| is provided by a class of frames that are based on Dunn’s compatibility frames. It is observed that this class coincides with one of the four classes giving the relational semantics for ILM and |${\textrm {ILM}}$|-|${\vee }$|⁠. (shrink)

We investigate model theoretic characterisations of the expressive power of modal logics in terms of bisimulation invariance. The paradigmatic result of this kind is van Benthem’s theorem, which says that a first-order formula is invariant under bisimulation if, and only if, it is equivalent to a formula of basic modal logic. The present investigation primarily concerns ramifications for specific classes of structures. We study in particular model classes defined through conditions on the underlying frames, with a focus on frame classes (...) that play a major role in modal correspondence theory and often correspond to typical application domains of modal logics. Classical model theoretic arguments do not apply to many of the most interesting classes–for instance, rooted frames, finite rooted frames, finite transitive frames, well-founded transitive frames, finite equivalence frames–as these are not elementary. Instead we develop and extend the game-based analysis over such classes and provide bisimulation preserving model constructions within these classes. Over most of the classes considered, we obtain finite model theory analogues of the classically expected characterisations, with new proofs also for the classical setting. The class of transitive frames is a notable exception, with a marked difference between the classical and the finite model theory of bisimulation invariant first-order properties. Over the class of all finite transitive frames in particular, we find that monadic second-order logic is no more expressive than first-order as far as bisimulation invariant properties are concerned — though both are more expressive here than basic modal logic. We obtain ramifications of the de Jongh–Sambin theorem and a new and specific analogue of the Janin–Walukiewicz characterisation of bisimulation invariant monadic second-order for finite transitive frames. (shrink)

We consider fixed point logics, i.e., extensions of first order predicate logic with operators defining fixed points. A number of such operators, generalizing inductive definitions, have been studied in the context of finite model theory, including nondeterministic and alternating operators. We review results established in finite model theory, and also consider the expressive power of the resulting logics on infinite structures. In particular, we establish the relationship between inflationary and nondeterministic fixed point logics and second order logic, and we consider (...) questions related to the determinacy of games associated with alternating fixed points. (shrink)

We consider Choiceless Polynomial Time , a language introduced by Blass, Gurevich and Shelah, and show that it can express a query originally constructed by Cai, Fürer and Immerman to separate fixed-point logic with counting from image. This settles a question posed by Blass et al. The program we present uses sets of unbounded finite rank: we demonstrate that this is necessary by showing that the query cannot be computed by any program that has a constant bound on the rank (...) of sets used, even in image, an extension of image with counting. (shrink)

We identify complete fragments of the simple theory of types with infinity and Quine’s new foundations set theory. We show that TSTI decides every sentence ϕ in the language of type theory that is in one of the following forms: ϕ=∀x1r1⋯∀xkrk∃y1s1⋯∃ylslθ where the superscripts denote the types of the variables, s1>⋯>sl, and θ is quantifier-free, ϕ=∀x1r1⋯∀xkrk∃y1s⋯∃ylsθ where the superscripts denote the types of the variables and θ is quantifier-free. This shows that NF decides every stratified sentence ϕ in the language (...) of set theory that is in one of the following forms: ϕ=∀x1⋯∀xk∃y1⋯∃ylθ where θ is quantifier-free and ϕ admits a stratification that assigns distinct values to all of the variables y1,…,yl, ϕ=∀x1⋯∀xk∃y1⋯∃ylθ where θ is quantifier-free and ϕ admits a stratification that assigns the same value to all of the variables y1,…,yl. (shrink)

A Theory of Magnitude suggests that space, time, and quantities are processed through a generalized magnitude system. ATOM posits that task-irrelevant magnitudes interfere with the processing of task-relevant magnitudes as all the magnitudes are processed by a common system. Many behavioral and neuroimaging studies have found support in favor of a common magnitude processing system. However, it is largely unknown whether such cross-domain monotonic mapping arises from a change in the accuracy of the magnitude judgments or results from changes in (...) precision of the processing of magnitude. Therefore, in the present study, we examined whether large numerical magnitude affects temporal accuracy or temporal precision, or both. In other words, whether numerical magnitudes change our temporal experience or simply bias duration judgments. The temporal discrimination paradigm was used to present numerical magnitudes across varied durations. We estimated temporal accuracy and precision for each numerical magnitude. The results revealed that temporal accuracy for large numerical magnitude was significantly lower than that of small and identical magnitudes. This implies that the temporal duration was overestimated for large numerical magnitude compared to small and identical numerical magnitude, in line with ATOM’s prediction. However, no influence of numerical magnitude was observed on temporal precision. The findings of the present study suggest that task-irrelevant numerical magnitude selectively affects the accuracy of processing of duration but not duration discrimination itself. Further, we argue that numerical magnitude may not directly affect temporal processing but could influence via attentional mechanisms. (shrink)

This note investigates the class of finite initial segments of the cumulative hierarchy of pure sets. We show that this class is first-order definable over the class of finite directed graphs and that this class admits a first-order definable global linear order. We apply this last result to show that FO = FO.

We sketch out two basic paradigms informing banking practice: the economistic paradigm focusing on profit maximization and the humanistic one, serving the common good. We then highlight paradigmatic cases to explore how each of these business models fared during the quasi-natural experiment of the financial crisis. We find that many humanistic banks outperformed traditional economistic banks. Despite the uneven playing field humanistic banks fared remarkably well with regard to traditional financial performance judgements, muting criticisms of competitiveness. We find that overall (...) both paradigms can provide a basis for successful banking as long as social and financial value generation are blended. We conclude by providing lessons learned for better banking. (shrink)

We consider the problem of obtaining logical characterisations of oracle complexity classes. In particular, we consider the complexity classes LOGSPACENP and PTIMENP. For these classes, characterisations are known in terms of NP computable Lindström quantifiers which hold on ordered structures. We show that these characterisations are unlikely to extend to arbitrary structures, since this would imply the collapse of certain exponential complexity hierarchies. We also observe, however, that PTIMENP can be characterised in terms of Lindström quantifers , though it remains (...) open whether this can be done for LOGSPACENP. (shrink)

Organizations have increasingly relied on team-based reward systems to boost productivity and foster collaboration. Drawing on the literature on ethics and justice as well as appraisal theories of emotion, we examine how team-based reward systems can have an insidious side effect: They increase the likelihood that employees remain silent when observing a team member engage in unethical behavior. Across four studies adopting different methods, measures, and samples, we found consistent evidence that people are less likely to report (i.e., speak up (...) or provide anonymous feedback about) a team member’s unethical behavior in team-based than in individual-based reward systems. Furthermore, our research reveals that this effect is primarily driven by a decrease in the experience of moral anger, which subsequently leads to a decreased likelihood of reporting unethical behavior when it benefits the team rather than the individual. We do not find support for perceived indirect benefit or envy as alternative explanations, suggesting that the decision to report a team member’s unethical behavior is not driven by calculative and selfish motives, but by moral motives. Finally, we establish that the effect is contingent on the observer and the perpetrator being members of the same team; it dissipates when the observer and the perpetrator are part of different teams. Our work contributes to research on reward systems and business ethics and provides practical implications for human resource practices. (shrink)

Political parties do not merely reflect social divisions, they actively construct them. While this point has been alluded to in the literature, surprisingly little attempt has been made to systematically elaborate the relationship between parties and the social, which tend to be treated as separate domains contained by the disciplinary division of labor between political science and sociology. This article demonstrates the constructive role of parties in forging critical social blocs in three separate cases, India, Turkey, and the United States, (...) offering a critique of the dominant approach to party politics that tends to underplay the autonomous role of parties in explaining the preferences, social cleavages, or epochal socioeconomic transformations of a given community. Our thesis, drawing on the work of Gramsci, Althusser, and Laclau, is that parties perform crucial articulating functions in the creation and reproduction of social cleavages. Our comparative analysis of the Republican and Democratic parties in the United States, Islamic and secularist parties in Turkey, and the Bharatiya Janata Party and Congress parties in India will demonstrate how “political articulation” has naturalized class, ethnic, religious, and racial formations as a basis of social division and hegemony. Our conclusion is that the process of articulation must be brought to the center of political sociology, simultaneously encompassing the study of social movements and structural change, which have constituted the orienting poles of the discipline. (shrink)

The main purpose of this article is to broaden U.S. scholars' awareness of the similarities and differences of gender literature in another part of the world. In providing this partial review of gender scholarship in India, the authors hope to foster critical reflection on the inequities of global knowledge production and consumption and the role of U.S. academic institutions and scholars in this project. The article is written not by scholars who are based in India but by those who are (...) based in U.S. academies. Given their location, linguistic and cultural competencies, and scholarly expertise, the review, at best, can be described as a glimpse of gender scholarship in India. The four sections of this article feature theoretical and methodological issues, the women's movement, and violence against women in India. (shrink)

There is considerable evidence that language comprehenders derive lexical-semantic meaning by mentally simulating perceptual and motor attributes of described events. However, the nature of these simulations—including the level of detail that is incorporated and contexts under which simulations occur—is not well understood. Here, we examine the effects of first- versus third-person perspective on mental simulations during sentence comprehension. First-person sentences describing physical transfer towards or away from the body modulated response latencies when responses were made along a front-back axis, consistent (...) with the action-sentence compatibility effect. This effect was not observed for third-person sentences. The ACE was observed when making responses along a left-right axis for third-person, but not first-person sentences.sentences did not show an ACE along either axis. These results show that perspective is a detail that is simulated during action sentence comprehension, and that motoric activations are flexible and affected by the pronominal perspective used in the sentence. (shrink)

Ibn al-ʻArabī, 1165-1240; views on freedom; Sufism; Islamic philosophy.